=== Commercial Performance ===
The album sold 160,000 copies in its first week of release in The United States, debuting at number 5, according to Billboard. Due to the album leaking on October 28, nearly four weeks ahead of the original release date of November 23, the album was released exclusively to itunes on November 9 and was physically released to stores on November 16, a week later. Due to this unique circumstance, 50 Cent's label Interscope requested that Billboard and Nielson Soundscan delay charting the album for a week, so the first week digital sales were added to the total amount of albums sold between November 16 and November 22. The album sold 46,000 copies during its itunes exclusive week, meaning that 114,000 copies were sold between November 16 and November 22.
The album fell 15 spots to number 20 on the billboard chart in its second week with sales of 66,000. In its third week the album fell 20 spots to number 40 with sales of 30,000. In its fourth week the album sold 23,000 falling to number 64 on the Billboard 200 albums chart. The album sold 26,000 copies in its 5th week to land at number 67 on the chart, and continued to slowly increase in sales during the holiday season for its sixth week, landing at number 61 on the Billboard charts with sales of 29,000. In the seventh week of sales the album sold 15,000 copies to land at number 42 on the Billboard 200. This was the last sales week of 2009, placing the album at year-end sales of 349,153 and making it the 111th best selling album of 2009, after seven weeks of sales.
Moving into 2010, in its eighth week of sales Before I Self Destruct sold 8,800 placing it at number 57. In its ninth week it sold 7,300 moving down to number 68. In its tenth week it sold 6,800 placing it at number 73 on the Billboard Top 200. In its eleventh week it sold 6,600 copies to land at number 89 on the Billboard 200 albums chart. In its twelfth week the album saw an increase in sales to 8,500 copies to land at number 73 on the Billboard 200 albums chart. In its 13th week it sold 8,100 copies to land at number 99 on the Billboard 200 chart. In its 14th week the album sold 7,000 copies to land at number 87 on the Billboard 200 chart. In its 15th week the album sold 8,400 copies to land at number 64 on the Billboard 200 chart. In its 16th week the album sold 5,800 copies to land at number 106 on the Billboard 200 chart. In its 17th week the album sold 5,000 copies to land at number 129 on the Billboard 200 albums chart. In its 18th week the album sold 4,300 copies to land at number 132 on the Billboard 200 chart. In its 19th week the album sold 3,700 copies to land at number 154 on the Billboard 200 albums chart. In its 20th week the album sold 3,600 copies to land at number 182 on the Billboard 200 albums chart. In its 21st week the album sold 2,500 copies, which was not enough to land in the Billboard Top 200 albums chart, however it landed at number 188 in the Top 200 Current Albums Chart. This was the last week the album would chart on the Billboard 200 or Billboard Top Current Albums Chart.
Before I Self Destruct has sold over 436,000 copies in the United States. As of January 21, 2010 the album has been certified Gold by the RIAA for shipment of more than 500,000 units.