I don't think it would be smart for 50 to diss Wayne. Fans have grown tired of 50 cent and his beefing. Plus, lil Wayne has most hip hop fans on his side right now. If I was 50 I wouldn't do it. The s*** will back fire on him.
The kid need Sha Money back. He need his good ears to say this is your lane and thats hot. Creating music but not releasing anything means u a lil confused. Admit that first then get that person to help you find ya niche